Upton was originally the home of the Nipmuc, who inhabited most of central Massachusetts. It was settled by Europeans migrants in 1728, and incorporated in 1735
- Home to Eli Whitney, inventor of the cotton gin
- The Grafton & Upton Railroad began in 1873 and still operates today.
- Knowlton Hat Factory was considered the largest hat industry in the world
- By 1873, Upton’s factories were producing 21.7% of all boots manufactured in Worcester County